Alexis Laurent Selected Research

N,N'- bis(pyridoxal- 5- phosphate)ethylenediamine- N,N'- diacetic acid (mangafodipir)

1/2012	Pretreatment with mangafodipir improves liver graft tolerance to ischemia/reperfusion injury in rat.
1/2011	Mangafodipir protects against hepatic ischemia-reperfusion injury in mice.
10/2009	Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis.
2/2006	Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir.
2/2005	Controlling tumor growth by modulating endogenous production of reactive oxygen species.

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Alexis Laurent Research Topics

Disease

44	Hepatocellular Carcinoma (Hepatoma) 11/2022 - 08/2003
37	Neoplasms (Cancer) 06/2021 - 07/2003
10	Fibrosis (Cirrhosis) 11/2022 - 01/2012
9	Neoplasm Metastasis (Metastasis) 12/2018 - 08/2003
6	Burns 08/2021 - 01/2020
6	Liver Cell Adenoma (Hepatocellular Adenoma) 07/2019 - 11/2015
4	Liver Diseases (Liver Disease) 01/2022 - 07/2003
4	Wounds and Injuries (Trauma) 12/2021 - 07/2008
4	Margins of Excision 11/2014 - 11/2007
3	Carcinogenesis 01/2022 - 02/2005
3	Necrosis 01/2020 - 11/2003
3	Focal Nodular Hyperplasia 01/2018 - 11/2015
3	Pneumoperitoneum 01/2018 - 11/2007
3	Hemorrhage 11/2017 - 04/2006
3	Thrombosis (Thrombus) 12/2015 - 07/2013
3	Colonic Neoplasms (Colon Cancer) 11/2009 - 02/2006
2	Obesity 01/2022 - 01/2014
2	Liver Failure 01/2022 - 04/2014
2	Ischemic Colitis 01/2020 - 11/2017
2	Liver Neoplasms (Liver Cancer) 01/2020 - 02/2016
2	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2019 - 01/2019
2	Abdominal Pain (Pain, Abdominal) 11/2017 - 09/2014
2	Reperfusion Injury 01/2012 - 01/2011
1	Cholangiocarcinoma 01/2022
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022
1	Tendinopathy (Tendonitis) 12/2021
1	End Stage Liver Disease 05/2021
1	Cicatrix (Scar) 02/2021
1	Hypertrophic Cicatrix (Hypertrophic Scar) 02/2021
1	COVID-19 01/2021
1	Ulcer 01/2021
1	Lung Diseases (Lung Disease) 01/2021
1	Rupture 09/2020
1	Peritoneal Neoplasms 09/2020
1	Infections 01/2020
1	Acute Kidney Injury (Acute Renal Failure) 01/2020
1	Incisional Hernia 03/2019
1	Non-alcoholic Fatty Liver Disease 01/2019
1	Hepatitis C 01/2019

Drug/Important Bio-Agent (IBA)

6	alpha-Fetoproteins (alpha-Fetoprotein)IBA 11/2022 - 11/2014
6	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2012 - 11/2003
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2018
5	CateninsIBA 10/2018 - 05/2012
5	N,N'- bis(pyridoxal- 5- phosphate)ethylenediamine- N,N'- diacetic acid (mangafodipir)FDA Link 01/2012 - 02/2005
4	Biological ProductsIBA 08/2021 - 01/2020
3	gadobenic acid (gadobenate dimeglumine)FDA Link 10/2020 - 11/2015
3	Contrast MediaIBA 10/2020 - 10/2018
3	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2020 - 01/2013
3	GadoliniumIBA 01/2018 - 01/2017
3	Sorafenib (BAY 43-9006)FDA Link 12/2017 - 10/2015
2	fluorocholineIBA 01/2022 - 10/2020
2	Fetal Proteins (Fetoprotein)IBA 09/2020 - 01/2020
2	BilirubinIBA 07/2015 - 10/2009
2	Mitogen-Activated Protein KinasesIBA 05/2012 - 02/2005
2	Paclitaxel (Taxol)FDA LinkGeneric 07/2006 - 02/2006
2	Pharmaceutical PreparationsIBA 02/2006 - 11/2003
2	AntioxidantsIBA 02/2005 - 05/2004
2	Superoxides (Superoxide)IBA 02/2005 - 05/2004
1	ABO Blood-Group SystemIBA 01/2022
1	A-factor (Streptomyces)IBA 01/2022
1	Bulk DrugsIBA 12/2021
1	Hyaluronic Acid (Hyaluronan)IBA 12/2021
1	Indicators and Reagents (Reagents)IBA 06/2021
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 02/2021
1	CytokinesIBA 02/2021
1	Therapeutic UsesIBA 01/2021
1	CollagenIBA 01/2021
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 10/2020
1	beta CateninIBA 01/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2020
1	AlbuminsIBA 01/2020
1	InterferonsIBA 01/2020
1	ApolipoproteinsIBA 01/2020
1	Apolipoproteins B (ApoB)IBA 01/2020
1	Proteins (Proteins, Gene)FDA Link 01/2020
1	PermacolIBA 03/2019
1	micaIBA 01/2019
1	Oxidoreductases (Dehydrogenase)IBA 01/2019

Therapy/Procedure

21	Liver Transplantation 01/2022 - 12/2006
20	Hepatectomy 11/2022 - 07/2003
7	Radiofrequency Ablation 01/2022 - 01/2012
6	Therapeutics 01/2021 - 02/2016
5	Drug Therapy (Chemotherapy) 02/2014 - 07/2007
4	Stents 01/2018 - 07/2007
3	Length of Stay 05/2021 - 11/2014
3	Contraindications 07/2015 - 01/2013
2	Immunotherapy 01/2022 - 01/2022
2	Transplantation 01/2019 - 01/2012
2	Cholecystectomy 01/2018 - 01/2014
2	Operative Time 11/2017 - 11/2014
2	Laparotomy 10/2017 - 04/2006
2	Lymph Node Excision (Lymph Node Dissection) 01/2015 - 05/2011
1	Ablation Techniques 05/2022
1	Aftercare (After-Treatment) 01/2022
1	Operative Surgical Procedures 06/2021
1	Skin Transplantation (Skin Grafting) 02/2021
1	Bandages (Bandage) 02/2021
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2021
1	Colectomy 01/2020
1	Drug Tapering 01/2019